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Leaky Vaccines: Antibody-Dependent Enhancement

The term “leaky vaccines” is given to a class of vaccines which have the potential to partake in a phenomenon referred to as “antibody dependent enhancement” or “ADE.” Other major concerns involve “viral shedding,” and “cytokine storms,” both which allow the mutated viruses from the infected host to spread the variant to surrounding unvaccinated individuals.

There are two types of vaccines which exist: “perfect vaccines”, and “leaky vaccines”. Perfect vaccines have the ability to block out a virus or disease completely, leaving no chance of infection from exposure. This results in sterilizing immunity. Leaky vaccines, only reduce the risk of symptoms upon exposure, and do not provide one-hundred percent infection from disease, or viruses.

This had led to scientific controversy for the use of leaky vaccines. Using research attained from animal studies, and real-world implementation, scientists were able to gather a greater insight into the potential risks associated with the reliance of “Leaky Vaccines” to combat mass viruses, and diseases. These correlations from the studies can be seen in the modern COVID-19 medical dictatorship, where consistent suggestion to get vaccinated overwhelms any other considerations.

Coronavirus concoctions are leaky vaccines. This means that despite their near one-hundred percent efficacy, they are not able to fully prevent infection of COVID-19. For this reason, masks are suggested to be worn at all times, in populated areas. As seen through trial and error, keeping consistent coverings over our airways is not conducive today’s way of life. In an attempt to remove the physical barrier placed over our faces, the majority of the world population has succumbed to mandated vaccinations.

How much have these mandated vaccinations helped society, and what can we learn from the past two years data since the Wuhan outbreak in December 2019. After this time, our planet seemingly entered a portal to another dimension, where the risk of infection greatly outweighed one’s individual civil rights. Lockdowns and life changing COVID-19 restrictions were set in place, many still existing in some form.

Yet over two years later, the pandemic drags on. Despite the mandated vaccines, masks, lockdowns, restrictions, guidelines, we as a human race just haven’t seem to get it right. Each country has implemented their own techniques, ranging from the Chinese Communist Party’s forced lockdowns over a single positive COVID-19 infection, to many countries choosing to use a more hands-off approach.

While the majority of American have been vaccinated, variants have emerged, reinstating mandates, inspiring new vaccines to be developed, in some countries doubling the doses originally required to participate in society. The mandatory COVID-19 vaccine rollout resulted in many questioning the efficacy of the newly created concoctions, their long term effects, and how long they would provide protection from exposure. Data from Israel’s fourth vaccine rollout showed an increase in positive COVID-19 cases, showing the vaccines were no longer effective towards preventing infection, but now used to decreased symptoms upon infection.

The COVID-19 concoctions do not provide sterile immunity, meaning they are not one-hundred percent effective in the prevention of SARS-CoV-2. These mandated vaccines are in fact considered “leaky vaccines” meaning they do not provide sterile immunity, allowing the virus to infect the body. With leaky vaccines, the difference between those vaccinated and unvaccinated, are the symptoms experienced upon infection. This report examines the known medical and scientific evidence surrounding leaky vaccines, and their effect during the COVID-19 pandemic.


Leaky Vaccine Studies – National Institutes of Health

The following eight studies are taken from researchers, scientists, and medical professionals around the world. Each instance holds indication that there are potential long-term concerns surrounding vaccines which do not completely prevent infections, such as SARS-CoV-2.

These studies will seek to answer at two basic questions:

  1. Can leaky vaccines provide a sustainable environment—an asymptomatic living host—for viruses and disease to mutate and re-replicate into stronger forms?
  2. Can leaky vaccines cause vaccine shedding to occur, causing potentially mutated viruses to infect the unvaccinated?

1) Leaky Vaccines Protect Highly Exposed Recipients at a Lower Rate: Implications for Vaccine Efficacy Estimation and Sieve Analysis

“Leaky Vaccines” is the term given to vaccines which do not completely [100%] prevent a virus or disease. In some cases, it makes the virus build up at high levels within the user, while no symptoms are present. This means the more vaccinated a patient becomes, the more susceptible they are to spreading the virus or disease to unvaccinated.

Leaky Vaccines Protect Highly Exposed Recipients at a Lower Rate: Implications for Vaccine Efficacy Estimation and Sieve Analysis1

“”Leaky” vaccines are those for which vaccine-induced protection reduces infection rates on a per-exposure basis, as opposed to “all-or-none” vaccines, which reduce infection rates to zero for some fraction of subjects, independent of the number of exposures.”

“Leaky vaccines therefore protect subjects with fewer exposures at a higher effective rate than subjects with more exposures.”

“This simple observation has serious implications for analysis methodologies that rely on the assumption that the vaccine effect is homogeneous across subjects.”

Source: Edlefsen PT. Leaky vaccines protect highly exposed recipients at a lower rate: implications for vaccine efficacy estimation and sieve analysis. Comput Math Methods Med. 2014;2014:813789. doi: 10.1155/2014/813789. Epub 2014 May 7. PMID: 24895500; PMCID: PMC4033482.


2) Waning of Measured Influenza Vaccine Effectiveness Over Time: The Potential Contribution of Leaky Vaccine Effect

Another study out of Atlanta viewed the impacts on the decline in effectiveness of flu vaccines over time, finding that it was a possible occurrence that needed to be addressed. Despite the medical fact of possible waning vaccine effectiveness, the medical dictatorship continues to advocate mass injections for all. In Israel, the Israeli Ministry of Health announced fourth vaccines to fight the effects of COVID-19, every four months. Should the waning of coronavirus vaccine effectiveness be something worth acknowledging?

Waning of Measured Influenza Vaccine Effectiveness Over Time: The Potential Contribution of Leaky Vaccine Effect

“Several observational studies have shown decreases in measured influenza vaccine effectiveness (mVE) during influenza seasons. One study found decreases of 6-11%/month during the 2011-2012 to 2014-2015 seasons.”

“These findings could indicate waning immunity but could also occur if vaccine effectiveness is stable and vaccine provides partial protection in all vaccinees (“leaky”) rather than complete protection in a subset of vaccinees.”

“Since it is unknown whether influenza vaccine is leaky, we simulated the 2011-2012 to 2014-2015 influenza seasons to estimate the potential contribution of leaky vaccine effect to the observed decline in [measured influenza vaccine effectiveness] mVE.”

“The leaky vaccine bias could account for some, but probably not all, of the observed intraseasonal decreases in [measured influenza vaccine effectiveness] mVE.”

“These results underscore the need for strategies to deal with intraseasonal vaccine effectiveness decline.”

Source: Tokars JI, Patel MM, Foppa IM, Reed C, Fry AM, Ferdinands JM. Waning of Measured Influenza Vaccine Effectiveness Over Time: The Potential Contribution of Leaky Vaccine Effect. Clin Infect Dis. 2020 Dec 17;71(10):e633-e641. doi: 10.1093/cid/ciaa340. PMID: 32227109; PMCID: PMC8422999.

3) Vaccine-Associated Enhanced Viral Disease: Implications for Viral Vaccine Development

One study published September 9, 2021, from Rockville, Maryland reviewed vaccine-associated enhanced disease. The research indicates both vaccine-associated hypersensitivity [ctyokine storms], as well as antibody-dependent enhancement as potential concerns for the SARS-CoV-2 virus.

Vaccine-Associated Enhanced Viral Disease: Implications for Viral Vaccine Development2

“Vaccine-associated enhanced disease (VAED) is a serious barrier to attaining successful virus vaccines in human and veterinary medicine. VAED occurs as two different immunopathologies, antibody-dependent enhancement (ADE) and vaccine-associated hypersensitivity (VAH).”

“The COVID-19 pandemic has produced widespread speculation that antibody-dependent enhancement (ADE) may jeopardize the safety of SARS CoV-2 vaccines or immunotherapies [12].”

“In humans, early in the 1960s, formalin-inactivated measles vaccines were introduced in the US and Europe. Within months, large numbers of vaccinated children developed ‘atypical measles’ [3].”

“A similar outcome, vaccine-associated enhanced respiratory disease (VAERD), was observed in infants 4–12 months of age, given formalin-inactivated respiratory syncytial virus (RSV) vaccines who a few months later were infected by RSV [4].”

“Recently, ADE [antibody-dependent enhancement] was identified as the cause of breakthrough severe dengue disease in seronegative children who had been given a yellow fever chimeric tetravalent dengue vaccine [56].”

“It has been known for some time that ADE [antibody-dependent enhancement] causes feline infectious peritonitis (FIP), a fatal Arthus-like pyogranulomatous coronavirus disease in vaccinated kittens and cats [79].”

“There is a large literature of vaccine failures in veterinary medicine, some of which are accompanied by enhanced breakthrough disease [89104]”

“It should be noted that, regardless of VAED response, viruses of many genera exhibit in vitro ADE [antibody-dependent enhancement].”

Source: Halstead SB. Vaccine-Associated Enhanced Viral Disease: Implications for Viral Vaccine Development. BioDrugs. 2021 Sep;35(5):505-515. doi: 10.1007/s40259-021-00495-6. Epub 2021 Sep 9. PMID: 34499320; PMCID: PMC8427162.


4) Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens

A 2015 study used Chickens to determine whether vaccines could have an effect on the evolution of viruses. The results indicated that vaccines had the ability to allow a virus to live and adapt in hosts which would normally cease to exist at a specific level of mutation. This results in unexpected consequences, including vaccines resistant variants.

Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens3

“Could some vaccines drive the evolution of more virulent pathogens?”

“Vaccines that keep hosts alive but still allow transmission could thus allow very virulent strains to circulate in a population.”

“There is a theoretical expectation that some types of vaccines could prompt the evolution of more virulent (“hotter”) pathogens. This idea follows from the notion that natural selection removes pathogen strains that are so “hot” that they kill their hosts and, therefore, themselves.”

“Vaccines that let the hosts survive but do not prevent the spread of the pathogen relax this selection, allowing the evolution of hotter pathogens to occur. This type of vaccine is often called a leaky vaccine.”

“When vaccines prevent transmission, as is the case for nearly all vaccines used in humans, this type of evolution towards increased virulence is blocked. But when vaccines leak, allowing at least some pathogen transmission, they could create the ecological conditions that would allow hot strains to emerge and persist.”

“Thus, the use of leaky vaccines can facilitate the evolution of pathogen strains that put unvaccinated hosts at greater risk of severe disease.”

Viral Shedding

“Chickens become infected with MDV by inhalation of dust contaminated with virus shed from the feather follicles of infected birds.”

“Vaccinated birds shed fewer virus genome copies than unvaccinated birds infected with the same viral strain.”

“By preventing death, vaccination greatly increased the infectious period of the most virulent strains, increasing the total amount of virus shed by several orders of magnitude, and increasing it above that of the least virulent strain.”

“To confirm that virus shed into the environment was a robust proxy for overall bird-to-bird transmission potential, we co-housed birds infected with our three most virulent strains with immunologically-naïve sentinel birds (Experiment 2).”

“When unvaccinated birds were infected with the two most lethal strains (Md5 and 675A), they were all dead within 10 days (Fig 2A), before substantial viral shedding had begun (S2 Fig).”

“Consequently, no sentinel birds in those isolators became infected (Fig 2B) and none died (Fig 2C). In contrast, when HVT-vaccinated birds were infected with either of those hyperpathogenic strains, they survived for 30 days or more (Fig 2A), allowing substantial viral shedding (S2 Fig). All co-housed sentinels consequently became infected (Fig 2B) and went on to die as a result of MDV infection (Fig 2C).”

“Thus, in accordance with the imperfect-vaccine hypothesis, vaccination enabled the onward transmission of viruses otherwise too lethal to transmit, putting unvaccinated individuals at great risk of severe disease and death.”

Source: Read AF, Baigent SJ, Powers C, Kgosana LB, Blackwell L, Smith LP, et al. (2015) Imperfect Vaccination Can Enhance the Transmission of Highly Virulent Pathogens. PLoS Biol 13(7): e1002198. https://doi.org/10.1371/journal.pbio.1002198

Penn State Elberly College of Science

Penn State Elberly College of Science released a video warning of the dangers of potential vaccine shedding, leading to the evolution of larger, and more destructive forms of viruses.

“When a vaccine works perfectly, as do the childhood vaccines for smallpox, polio, mumps, rubella and measles, it prevents vaccinated individuals from being sickened by the disease, and it also prevents them from transmitting the virus to others,” said Andrew Read, an author of the study and an Evan Pugh professor of biology and entomology and Eberly professor in biotechnology at Penn State University.

Watch the full video here4


5) Porcine Reproductive and Respiratory Syndrome Modified Live Virus Vaccine: A “Leaky” Vaccine with Debatable Efficacy and Safety

One Beijing study published on April 9th, 2021 used pigs to test the effects of vaccine shedding using a modified live virus through the use of leaky vaccines. The results found that modified live viruses can still replicate, encouraging viral mutations to occur within the host. This means that leaky vaccines have the potential to create stronger variants of viruses, an alarming notion considering that COVID-19 vaccines do not prevent COVID-19 infections, and do not offer one-hundred percent immunity.

Porcine Reproductive and Respiratory Syndrome Modified Live Virus Vaccine: A “Leaky” Vaccine with Debatable Efficacy and Safety5

“MLV [modified live-virus] can induce a protective immune response against homologous viruses by lightening the clinical signs of pigs and reducing the virus transmission in the affected herd, as well as helping to cost-effectively increase the production performance on pig farms affected by heterologous viruses.”

“MLV [modified live-virus] can still replicate in the host, inducing viremia and virus shedding, and it fails to confer sterilizing immunity against PRRSV infection, that may accelerate viral mutation or recombination to adapt the host and to escape from the immune response, raising the risk of reversion to virulence.”

“The unsatisfied heterologous cross-protection and safety issue of MLV [modified live-virus] are two debatable characterizations, which raise the concerns that whether it is necessary or valuable to use this leaky vaccine to protect the field viruses with a high probability of being heterologous.”

Source: Zhou L, Ge X, Yang H. Porcine Reproductive and Respiratory Syndrome Modified Live Virus Vaccine: A “Leaky” Vaccine with Debatable Efficacy and Safety. Vaccines (Basel). 2021 Apr 9;9(4):362. doi: 10.3390/vaccines9040362. PMID: 33918580; PMCID: PMC8069561.


6) Sharing CD4+ T Cell Loss: When COVID-19 and HIV Collide on Immune System

A study published December 15th, 2020 discussed reduction in T cell Counts in COVID-19 patients, and T cell response compared to HIV. Additionally this study described cytokine storms, a phenomenon which causes mass inflammation which is difficult to diagnose, and current treatments are limited.

Sharing CD4+ T Cell Loss: When COVID-19 and HIV Collide on Immune System6

“COVID-19 is a distinctive infection characterized by elevated inter-human transmission and presenting from absence of symptoms to severe cytokine storm that can lead to dismal prognosis. Like for HIV, lymphopenia and drastic reduction of CD4+ T cell counts in COVID-19 patients have been linked with poor clinical outcome.”

“As CD4+ T cells play a critical role in orchestrating responses against viral infections, important lessons can be drawn by comparing T cell response in COVID-19 and in HIV infection and by studying HIV-infected patients who became infected by SARS-CoV-2.”

“We critically reviewed host characteristics and hyper-inflammatory response in these two viral infections to have a better insight on the large difference in clinical outcome in persons being infected by SARS-CoV-2.”

“The better understanding of mechanism of T cell dysfunction will contribute to the development of targeted therapy against severe COVID-19 and will help to rationally design vaccine involving T cell response for the long-term control of viral infection.”

Source: Peng X, Ouyang J, Isnard S, Lin J, Fombuena B, Zhu B, Routy JP. Sharing CD4+ T Cell Loss: When COVID-19 and HIV Collide on Immune System. Front Immunol. 2020 Dec 15;11:596631. doi: 10.3389/fimmu.2020.596631. PMID: 33384690; PMCID: PMC7770166.

Related: What are Cytokine Storms?


7) Infectious Bronchitis Virus Evolution, Diagnosis and Control

Infectious Bronchitis Virus Evolution, Diagnosis and Control7 studies have been conducted by four Italian scientists from the Department of Animal Medicine stated their views on using inline automatic sprayers to “spray droplets” into the lungs, “mimicking the entrance of respiratory viruses.” The researchers cite that spray vaccines are replacing “administration via drinking water.” Will Americans see these totalitarian techniques begin to become normalized before subjecting the U.S. population to “mass spray vaccinations”, or placing COVID-19 preventatives into our public drinking water? Nasal vaccines have already been invented8 with clinical trials underway in many countries including Russia9.

“RNA viruses are characterized by high mutation and recombination rates, which allow a rapid adaptation to new environments.”

“Mass spray vaccination is an approach that clearly minimizes work whilst maximizing coverage, and it is usually applied at hatchery or farm by spray, which is considered analogous to the gold standard oculo-nasal vaccination in mimicking the entrance of respiratory viruses [120,130], when properly managed. However, improper settings of the diameter of the sprayed droplets can cause a deep penetration of the vaccine virus in the lungs and consequent vaccine reactions [120].”

“Spray vaccination could raise managerial problems when applied in a hatchery that supplies chicks to several farms requesting different vaccines. Nonetheless, the concern of chick contamination with different administered strains at the hatchery was diminished by Pellattiero et al., proposing that not yet replicating vaccines seem unable to spread to other non-vaccinated animals located in the same environment for several hours [131].”

“Spray vaccination has been progressively replacing administration via drinking water, which is largely deprecated since it often implies the combination of vaccines and other substances, normally dissolved in the water or to be co-administered, that could lower the vaccine titre or viability, leading to low coverage, rolling reactions and reversion to virulence.”

“Nevertheless, it is still used, mainly for booster administration of less attenuated vaccines in the field”

Legnardi M, Tucciarone CM, Franzo G, Cecchinato M. Infectious Bronchitis Virus Evolution, Diagnosis and Control. Vet Sci. 2020 Jun 22;7(2):79. doi: 10.3390/vetsci7020079. PMID: 32580381; PMCID: PMC7356646.


8) Pathogen transmission from vaccinated hosts can cause dose-dependent reduction in virulence

A team of seven scientists, (four from the United Kingdon, and three from America) studied the effects of Marek disease virus (MDV) in chickens to observe the use of leaky vaccines substantially reduced viral load in both vaccinated and unvaccinated contact they infected.

Pathogen transmission from vaccinated hosts can cause dose-dependent reduction in virulence10

“Many livestock and human vaccines are leaky because they block symptoms but do not prevent infection or onward transmission.

“This leakiness is concerning because it increases vaccination coverage required to prevent disease spread and can promote evolution of increased pathogen virulence.”

“Despite leakiness, vaccination may reduce pathogen load, affecting disease transmission dynamics. However, the impacts on post-transmission disease development and infectiousness in contact individuals are unknown.”

“Here, we use transmission experiments involving Marek disease virus (MDV) in chickens to show that vaccination with a leaky vaccine substantially reduces viral load in both vaccinated individuals and unvaccinated contact individuals they infect.”

“Consequently, contact birds are less likely to develop disease symptoms or die, show less severe symptoms, and shed less infectious virus themselves, when infected by vaccinated birds.”

“These results highlight that even partial vaccination with a leaky vaccine can have unforeseen positive consequences in controlling the spread and symptoms of disease.”

Source: Bailey RI, Cheng HH, Chase-Topping M, Mays JK, Anacleto O, Dunn JR, Doeschl-Wilson A. Pathogen transmission from vaccinated hosts can cause dose-dependent reduction in virulence. PLoS Biol. 2020 Mar 5;18(3):e3000619. doi: 10.1371/journal.pbio.3000619. PMID: 32134914; PMCID: PMC7058279.


Conclusion

In American major cities, such as New York City, vaccine mandates have been set in place to prevent the spread of SARS-CoV-2. When boosters were announced, many began to realize this was quickly becoming a pandemic of control, one that now seemingly, may be never be going away. One-dose ahead of the curve, Israel hosted its residents to function as the global experiment for the continuous production of Spike Proteins throughout the body. Now, at four vaccines, the data has begun to reveal that these controversial vaccines could play a role in the asymptomatic transmission of COVID-19 to unvaccinated individuals. Without symptoms, the host would be able to withstand a more powerful mutation of the SARS-CoV-2 virus, leading to greater chance of variants producing increased infection throughout those who are unable or unwilling to inject the experimental concoctions.

If the current existing leaky vaccines being touted as necessary prophylactics are responsible for allowing the manifestation of increasingly severe variants of the virus, it would mean that the bureaucratic iatrarchy and the Biden Administration are knowingly propagating this pandemic for financial profit and authoritative control. Are leaky vaccines the cause for this high amount of both positive COVID-19 cases and unvaccinated deaths happening in Israel? If so, what damage does the SARS-CoV-2 Spike Protein cause biologically, with no symptoms present? Could COVID-19 concoctions be knowingly mandated upon the population, causing stronger variants to emerge, perpetuating the SARS-CoV-2 pandemic?

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