Big Pharma CDC Controversial Coronavirus FDA Genomics Health mRNA Nanotechnology Science Vaccines

The Rise of Nanoparticles

Nanoparticles are everywhere, and in everything. Nanoparticles enter through the skin, lungs, liver, digestive system and other areas of the human body. There are many kinds of nanoparticles, however the common factor in all forms is their size. In medicine, nanoparticles are synthetically manufactured to attempt hiding the nanoparticle from our immune system, increasing the efficacy and reducing cell membrane and DNA damage.

The nanoparticles used in coronavirus concoctions are fat vesicles (fat bubbles) that stick to cell membranes, which allow the transmission of mRNA ingredients inside the cell. Due to the size of these particles, they can enter our bodies undetected by the immune system. The mRNA provides the [previously unknown] blueprint, to create the protein within the DNA. In the case of coronavirus, the mRNA causes the cell’s DNA to begin producing spike protein antibodies.

The mRNA-lipid nanoparticles (LNP) used in the COVID-19 “vaccines” must be stored at very low temperatures in order to preserve their efficacy.


How Cells React to mRNA

Cells have three basic sections

  • Cell Membrane
  • Cytoplasm
  • Nucleus
Image Source: genome.gov

Inside the Nucleus is a substance Chromatin, which is where our DNA exists. In addition to DNA, RNA and protein also inhabit Chromatin. This area is responsible for the production of the spike proteins, following a coronavirus injection.

Image Source: genome.gov

How mRNA works

  1. mRNA is inserted into a lipid nanopartical
  2. The concoction is injected into the patient
  3. Nanoparticles stick to the cell membranes
  4. Nanoparticles pass through the cell membrane and the acid from the cell begins dissolving the outer layer [PEG] of the nanoparticle
  5. The exposed nanoparticle becomes positively charged and the directed and the mRNA ingredients are then passed into the cell’s cytoplasm
  6. The cell starts the production of spike proteins
  7. The spike protein is recognized by the body’s immune system
  8. CoV-2 antibody production begins
  9. The body produces an immunity response to COVID-19
  10. Antibody levels continue to increase over time, until the vaccine reaches maximum efficacy
Image Source: Acuitas Theraputics
Image Source: Acuitas Theraputics

Synthetic mRNA delivered in LNP

Image Source: Acuitas Theraputics

Loss of PEG-lipid from the LNP surface allows binding of ApoE

Image Source: Acuitas Theraputics
Image Source: beyond.ubc.ca

This combination of modified genetics is called an mRNA-lipid nanoparticle. mRNA is negatively charged, and repelled by the same negatively charged cell membrane. Therefore, researchers found positively charged lipid molecules helped the LNP enter into the membrane of the cell. Positively charged LNP are traditionally hepatotoxic (damaging to the liver) upon accumulating in the liver.


Why use Synthetic Nanoparticles?

Synthetic creation of nanoparticles allow scientists to modify the consistency and shape of the nanoparticle, allowing it to be disguised from our immune system. These modifications also help the nanoparticles to stick to the cells easier, causing less possibility of organ damage.

Lipid nanoparticles often contain other substances [lipids] to allow better cell binding. These substances include:

PEG Warning

Scientists warn that patients who take the coronavirus vaccines containing PEG may develop antibodies to the substance. This means in the future, giving an injection of nanoparticles containing PEG could trigger an anaphylactic reaction.

Image Source: cen.acs.org

Dangers of Nanoparticles

Harmful effects depends on the individual, their level of exposure, and the composition and shape of the nanoparticle. Much of the long term dangers of nanoparticles is still greatly unknown. The harmful ecotoxicological effects of synthetic nanoparticles also lack research.

“Despite the small mass of nanoparticles, their toxicological impact could be significant.”National Institutes of Health

The National Institutes of Health (NIH), states in their International Journal of Nanomedicine that “nanoparticles could also cause new types of effects not previously seen with larger particles (eg, mitochondrial damage, uptake through olfactory epithelium, platelet aggregation, cardiovascular effects).”

Immunocompromised individuals may also be at risk of the health risks of nanoparticles, with the NIH stating, “In addition, epidemiological evidence suggests that these effects occur predominantly in subjects that have an impaired health.”

Nanoparticles do not dissolve in water. Nanoparticles can easily cross the blood brain barrier, and may be toxic to the brain. The goal is to get the nanoparticles to stick to our cells, before they are attacked by our immune system.

Even though nanoparticles are used to get the mRNA into our cells, nanoparticles may also cause cell membrane or DNA damage. As the use of nanoparticles in medicine continues to rise, the full extent of nanotechnology’s long term effects is still largely unknown.

According a report from nature.com, “SARS-CoV-2 mRNA has been recovered from the cerebrospinal fluid, suggesting it can cross the blood–brain barrier (BBB). Other coronaviruses, including the closely related SARS virus that caused the 2003–2004 outbreak, are able to cross the BBB, and SARS-CoV-2 can infect neurons in a BrainSphere model.”


mRNA Lipid Nanoparticles Found in Coronavirus Vaccines

The mRNA coronavirus concoctions ingredients show the various combination of synthetic nanoparticles:

Ingredients in Comirnaty (Pfizer-BioNTech)

Genotoxicity (DNA damage), carcinogenicity (cancer), and the effects on male fertility, has not been evaluated in Comirnaty, Pfizer-BioNTech’s new coronavirus concoction. However in a study with rats, there were no vaccine-related effects on female fertility.

Each 0.3 mL dose of the COMIRNATY includes the following ingredients:

Each vial must be diluted with 1.8 mL of sterile 0.9% Sodium Chloride Injection, USP prior to use to form the vaccine.

  • 30 mcg of a nucleoside-modified messenger RNA (mRNA) encoding the viral spike (S) glycoprotein of SARS-CoV-2.
  • lipids
    • 0.43 mg ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate),
  • 0.05 mg 2-(polyethylene glycol 2000)-N,N-ditetradecylacetamide
  • 0.09 mg 1,2-distearoyl-sn-glycero-3-phosphocholine
  • 0.2 mg cholesterol)
  • 0.01 mg potassium chloride,
  • 0.01 mg monobasic potassium phosphate
  • 0.36 mg sodium chloride,
  • 0.07 mg dibasic sodium phosphate dihydrate
  • 6 mg sucrose.
  • The diluent (0.9% Sodium Chloride Injection, USP) contributes an additional 2.16 mg sodium chloride per dose.
    • COMIRNATY does not contain preservative.
    • The vial stoppers are not made with natural rubber latex.

Read the full package insert here


Moderna’s “Vaccine” Ingredients

What are ingredients of the Moderna vaccine?

The Moderna COVID-19 Vaccine, and booster, contains the following ingredients:

  • messenger ribonucleic acid (mRNA)
  • lipids
    • SM-102
    • polyethylene glycol [PEG] 2000 dimyristoyl glycerol [DMG]
    • cholesterol,
    • 1,2-distearoyl-sn-glycero-3-phosphocholine [DSPC])
  • tromethamine
  • tromethamine hydrochloride
  • acetic acid
  • sodium acetate trihydrate
  • sucrose.

Read the full package insert here


SM-102

What is SM-102?

SM-102 is a synthetic lipid used in combination with other lipids (fat vesicles) to form a nanoparticle for use with mRNA delivery. This very artificial substance is [partially] responsible for the effectiveness of Moderna’s mRNA concoction.

The Safety Data Sheet for the substance SM-102 states it to be a “health hazard” claiming it “may cause cancer”.

SM-102 is also known to cause the following acute and delayed symptoms:

  • Anemia
  • Cough
  • CNS Depression
  • Drowsiness
  • Headache
  • Heart Damage
  • Lassitude (weakness, exhaustion)
  • Liver Damage
  • Narcosis
  • Reproductive “effects”
  • Teratogenic “effects”

Read the full SM-102 Safety Data Sheet here


The Study of Nanoparticles

Engineers at the University of California, San Diego have developed a new technology that uses an oscillating 15kHz electric field to identify vaccine nanoparticles in patients blood.

Image: NP removal chip and dime

Nanoparticles are difficult to separate from plasma, the liquid component of blood, due to their small size and low density.

Traditional methods to remove nanoparticles do not work in all instances, and often include:

  • diluting the blood’s plasma
  • adding a concentrated sugar to the plasma and spinning it in a centrifuge
  • attaching a targeting agent to the surface of the nanoparticles

“This is the first example of isolating a wide range of nanoparticles out of plasma with a minimum amount of manipulation,” said Stuart Ibsen, of the Department of NanoEngineering at UC San Diego. Ibsen added, “We’ve designed a very versatile technique that can be used to recover nanoparticles in a lot of different processes.”

The new nanoparticle separation technology will enable researchers to better understand what happens to the buildup of nanoparticles circulating throughout a patient’s bloodstream.

“We were interested in a fast and easy way to take these nanoparticles out of plasma so we could find out what’s going on at their surfaces and redesign them to work more effectively in blood,” said Michael Heller, a nanoengineering professor at the UC San Diego Jacobs School of Engineering.


Who owns the most patents for nanotechnology?

According to 2019 data from statnano.com:

  • IBM holds 791 patents for nanotechnology
  • Samsung holds 515 patents for nanotechnology
  • Intel holds 361 patents for nanotechnology
  • BOE technology group holds 305 patents for nanotechnology
  • Taiwan Semiconductor Manufacturing holds 285 patents for nanotechnology
  • Samsung Display holds 260 patents for nanotechnology
  • The Regents of the University of California holds 258 patents for nanotechnology
  • The United States government holds 206 patents for nanotechnology
  • Hon Hai Precision Industry holds 196 patents for nanotechnology
  • Tsinghua University holds 186 patents for nanotechnology

Could these patents financially incentivize these companies to pressure the increased use of nanotechnology in modern medicine?


Conclusion

While there are documented benefits and medical reliance on nanoparticles, further research needs to be done to understand the long term effects on human cell membranes and DNA. Could the excessive buildup of nanoparticles weaken the immune system, or cause organ malfunction?

Will the rise of nanotechnology create a larger potential of future health concerns? How could the increased use of nanoparticles in modern medicine impact the health of future generations? Should mandated nanotechnology be a choice?

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